The Effect of Stimuli-Responsive Smart Nanoparticles in the Treatment of Central Nervous System Tumors

Introduction:In recent years, significant advances have been made in nanotechnology and medicine, particularly in the treatment of nervous system tumors such as glioblastoma.Glioblastoma, as the most common and aggressive brain tumor, with an average survival of less than 15 months, has created serious challenges for current treatments, such as surgery and chemotherapy.Smart nanoparticles (SNs), a new generation of nanoparticles with the ability to cross the blood-brain barrier and selectively target tumor cells, have provided new hope to overcome these challenges.SNs can release drugs in a controlled manner in response to specific stimuli such as changes in pH or temperature, which increases the effectiveness of treatment and reduces side effects.SNs have various applications in the treatment of nervous system tumors and can significantly improve the effectiveness of chemotherapy drugs.Despite the remarkable successes, challenges such as the safety and toxicity of nanoparticles and scaling mass production difficulties still exist.However, technological advances can help solve these issues.Finally, SNs are recognized as a powerful tool in the treatment of central nervous system tumors and can play an important role in improving treatment methods.Conclusion: Considering its significant therapeutic potential, this review summarizes the effects of stimuli-responsive SNs and highlights their role in the treatment of central nervous system tumors.