Sulfonium Salt-Mediated Difunctionalization of Alkynes for Access to <i>Z</i>-Alkenyl Phosphorothioates and Selenophosphates
In this work, we present a practical and efficient one-pot sulfonium salt-mediated difunctionalization reaction of alkynes. This method facilitates the diverse synthesis of various alkenyl phosphorthioates and selenophosphates in acceptable yields. Importantly, the reaction is completely regio- and stereoselective, producing absolutely <i>Z</i>-configured alkenylated phosphorothioates and selenophosphates with a broad substrate scope and high functional group tolerance.
Authors
- Li Tang (ORCID: https://orcid.org/0000-0003-4689-361X)
- Long‐Yong Xie (ORCID: https://orcid.org/0000-0002-8932-7282)
- Ni-Dan Meng
- Sha Peng (ORCID: https://orcid.org/0000-0003-2411-6414)
- Xinhua Xu (ORCID: https://orcid.org/0000-0001-7139-1246)
- Li‐Hua Yang (ORCID: https://orcid.org/0000-0001-7106-3015)
Institutions
- Hunan University of Science and Engineering (CN)
- Bioengineering Center (RU)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-07-20
- DOI
- https://doi.org/10.1021/acs.orglett.5c02426
- Citations
- 9
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 8.42
Funders
- National Natural Science Foundation of China
- Scientific Research Foundation of Hunan Provincial Education Department