Annulation of Enyne-Amide with Enaminone Enables Divergent Synthesis of Furo[2,3-<i>b</i>]pyridine Derivatives
A wide range of furo[2,3-<i>b</i>]pyridine and furo[2,3-<i>b</i>]dihydropyridine derivatives, which might be of value in biomedicinal chemistry and materials science, are divergently delivered through Ag(I)-catalyzed tandem cycloisomerization/cyclization reactions between enyne-amides and enaminones just by tuning the reaction conditions. The products could be conveniently transformed into various derivatives.
Authors
- Xin Lv (ORCID: https://orcid.org/0000-0002-5431-4529)
- Hui Mao (ORCID: https://orcid.org/0000-0002-2494-4132)
- Hui Yang (ORCID: https://orcid.org/0000-0002-2228-5233)
- Liejin Zhou (ORCID: https://orcid.org/0000-0003-3929-2525)
- Zefeng Jin
- Honglan Kang (ORCID: https://orcid.org/0000-0002-1346-4221)
- Cuiying Li
- Ziyan Ji
Institutions
- Zhejiang Normal University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-07-20
- DOI
- https://doi.org/10.1021/acs.orglett.5c02452
- Citations
- 2
- Primary Topic
- Catalytic Alkyne Reactions
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China
- Jinhua Science and Technology Bureau
- Natural Science Foundation of Zhejiang Province