Bromodifluoromethyl Phenoxathiinium Salt: A Practical and Competent Reagent Enabling Visible-Light-Promoted Bromodifluoromethylation of C(sp<sup>3</sup>)–H and Alkenes
A novel bromodifluoromethyl phenoxathiinium salt (BrF<sub>2</sub>C-PXT<sup>+</sup>) is reported as an exceptionally reactive and versatile bromodifluoromethylating reagent, demonstrating unprecedented photoredox-catalyzed C(sp<sup>3</sup>)-H bromodifluoromethylation and EDA-mediated hydrobromodifluoromethylation of alkenes under mild visible-light irradiation with high efficiency, a broad substrate scope, and good functional group tolerance. Furthermore, the late-stage bromodifluoromethylative modification of a series of bioactive compounds was also explored. This innovative BrF<sub>2</sub>C-PXT<sup>+</sup> is a promising platform reagent for creating a variety of valuable bromodifluoromethylated architectures.
Authors
- Guo‐Kai Liu (ORCID: https://orcid.org/0000-0001-7617-4267)
- Ya-Ru Feng
- Hongrui Li (ORCID: https://orcid.org/0000-0002-2571-1883)
- Hong‐Xin Long
- Mei-Feng Ruan
Institutions
- Shenzhen University (CN)
- Southern University of Science and Technology (CN)
- Shenzhen University Health Science Center (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-07-20
- DOI
- https://doi.org/10.1021/acs.orglett.5c02262
- Citations
- 1
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.79
Funders
- Basic and Applied Basic Research Foundation of Guangdong Province