New cytotoxic <i>p</i> -hydroxybenzoic acid and sesquiterpene-derived amides from <i>Aspergillus fumigatus</i> J2-22-1
Two new amides (<b>1</b>-<b>2</b>) derived from <i>p</i>-hydroxybenzoic acid and sesquiterpene, respectively, along with one known sesquiterpene (<b>3</b>), were isolated from the desert soil-derived fungus <i>Aspergillus fumigatus</i> J2-22-1. Structural characterisation was achieved through spectroscopic analysis, with absolute configurations confirmed <i>via</i> comparative ECD spectra. The anticancer potential of these compounds was evaluated against four human tumour models: MCF-7, SGC-7901, MGC-803, and HepG2. Notably, all test compounds -displayed broad-spectrum cytotoxic activities (IC<sub>50</sub> values: 20.17-94.83 μM).
Authors
- D. Luo (ORCID: https://orcid.org/0009-0007-6469-1698)
- Nanxin Gong (ORCID: https://orcid.org/0000-0001-8680-1121)
- Xiaomei Song (ORCID: https://orcid.org/0000-0003-1906-1578)
- Yurun Wang
- Wenjie Han
- Huiying Liu (ORCID: https://orcid.org/0000-0003-3431-4836)
- Meng Ren
- Jun Zhang (ORCID: https://orcid.org/0000-0001-9250-9450)
- Hong‐Liang Tang (ORCID: https://orcid.org/0000-0002-1597-0603)
- Taoshuai Cao
- Xiaolong Zhao (ORCID: https://orcid.org/0009-0007-8443-6627)
- Xupei Men
Institutions
- Life Science Institute (JP)
- Hebei University (CN)
Publication Details
- Journal
- Natural Product Research
- Published
- 2025-07-20
- DOI
- https://doi.org/10.1080/14786419.2025.2534684
- Primary Topic
- Fungal Biology and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China