Skeletal Muscle Memory and Its Implications

Skeletal muscle memory can be defined as the ability of skeletal muscle to respond differently to stimuli encountered before. However, the forming mechanism of skeletal muscle memory is not concrete. It has been proposed that myonuclear increase and epigenetic modification are the leading causes of skeletal muscle memory. This article will briefly review the literature on the development and supporting evidence of the two theories. Meanwhile, the implications of skeletal muscle memory in sarcopenia and anti-aging treatment will be discussed. The review concludes that existing studies have shown many unknown issues and inconsistencies, which may indicate future research directions.