Recent Advances in Prevention and Control Strategies for Bovine Respiratory Disease

Bovine respiratory disease (BRD) is a complex and economically significant illness in cattle, with a multifactorial origin involving pathogens, environmental conditions, and management practices. Recent studies highlight a strong genetic component in BRD susceptibility and resistance. From a genetic perspective, key technologies such as high-throughput RNA sequencing, RNA interference (RNAi), CRISPR-Cas9 gene editing, and genomic selection are being widely applied to uncover molecular mechanisms and enhance genetic resistance to BRD. These approaches offer promising avenues for precision breeding and targeted intervention. In addition to genetic strategies, emerging technologies such as nanomedicines and microbial preparations are gaining popularity as innovative tools for BRD prevention and treatment. This article discusses these developments and their potential to reduce antibiotic dependence and promote sustainable cattle health management.