Current Understanding and Therapeutic Advances in Alzheimers Disease

The number of people with Alzheimers Disease (AD) continues to rise because of global population ages. This disease seriously threatening human health and quality of life. This article systematically reviews the pathogenesis of AD and existing treatments. Amyloid protein (A) deposition, tau protein abnormalities, neuroinflammatory responses, and acetylcholine dysfunction are the primary pathological mechanisms of AD. These factors work together to can cause the death and dysfunction of neuronal, clinical manifestations memory impairment and disorders of language. There is currently no drug or vaccine that can cure AD, but a variety of treatments have been used to mitigate the spread of the state of an illness and relieve symptoms of patients. The FDA has approved the immunotherapy drugs lecanemab and donanemab targeting A. At the same time, acetylcholinesterase inhibitors are also widely used to treat AD. In addition, psychological interventions such as cognitive stimulation therapy and cognitive rehabilitation also have a positive effect on maintaining patient function. This article aims to help readers get a better comprehending of the causing and treatment status of AD which can enhance public awareness and tolerance of the disease. In the future, AD research will still face many challenges, but with the continuous exploration of new targets, strategies of treatment, the comprehensive prevention and treatment of AD is still full of hope.