MeCP2 dysregulation inhibits mitophagy and impairs neural development in cortical organoids
The obtained findings demonstrate that MeCP2 regulates mitophagy by modulating BNIP3L expression, and its dysfunction leads to mitochondrial accumulation and neurodevelopmental abnormalities. The present study highlights the critical role of MeCP2 in maintaining mitochondrial homeostasis and provides insights into the molecular mechanisms underlying MeCP2-related neurodevelopmental disorders.
Authors
- Dongdong Tong
- Jiangfang Lian (ORCID: https://orcid.org/0000-0002-3573-8051)
- Yuchun Liu
- W. Li (ORCID: https://orcid.org/0000-0002-3629-9548)
- Hang Peng (ORCID: https://orcid.org/0000-0003-3615-4522)
- Jing Zhou (ORCID: https://orcid.org/0000-0001-9814-6574)
- Xiaofei Wang (ORCID: https://orcid.org/0000-0002-7704-4445)
- Chenfu Huang (ORCID: https://orcid.org/0000-0002-5563-6722)
- Rufeng Li
- Fang Li (ORCID: https://orcid.org/0000-0001-5456-0255)
- Jinyuan Zhang (ORCID: https://orcid.org/0000-0002-5072-4934)
- Xintao Jing (ORCID: https://orcid.org/0000-0001-9080-4421)
- Cao Li (ORCID: https://orcid.org/0000-0002-3500-340X)
Institutions
- Shanxi Medical University (CN)
- Shaanxi Provincial People's Hospital (CN)
- Xi'an Medical University (CN)
- Ningbo Medical Center Lihuili Hospital (CN)
- Jiangxi Provincial Children's Hospital (CN)
- Shanxi Provincial People’s Hospital (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-07-19
- DOI
- https://doi.org/10.1016/j.jare.2025.07.035
- Citations
- 1
- Primary Topic
- Genetics and Neurodevelopmental Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- National Natural Science Foundation of China