Correlation between time to postoperative seizure onset and time to tumor progression in a cohort of adult-type diffuse gliomas with molecular characterization

The development of seizures after surgery might predict a risk of tumor progression if they occur beyond a postoperative period unique to IDH status. Specifically, an MDM2 mutation and presentation with seizures were strong predictors of tumor progression in glioblastoma (GBM). SETD2 and NIPBL mutations might predict greater seizure freedom in GBM and IDH-mutant gliomas, respectively.