[Diagnosis and treatment of hepatitis E virus: Guidelines of the Czech Society for Infectious Diseases].

Hepatitis E virus (HEV) is currently one of the most common causes of acute viral hepatitis. The Czech Republic is a region with a natural occurrence of genotype 3 HEV (HEV-3). The disease caused by this genotype has specific characteristics. The predominant route of transmission is zoonotic, through undercooked meat or offal from reservoir animals. Most infections are asymptomatic. Symptomatic hepatitis E may present as acute hepatitis with non-specific symptoms of viral infection and elevated serum aminotransferase activity, or it may lead to liver failure and death. Additionally, numerous extrahepatic manifestations and the potential for chronic hepatitis development in immunocompromised patients have been described. The article provides a comprehensive summary of current recommendations for the diagnosis and treatment of hepatitis E virus infections in the context of the Czech Republic.