The effect of Hydrocortisone on implantation through upregulation of tight junction genes: A lab trial study
In conclusion, Hydrocortisone treatment (at 100 nm concentration) significantly increased the expression of tight junction genes, suggesting that the blastocyst cannot infiltrate the endometrium readily, thus preventing implantation. Glucocorticoids can disrupt implantation by influencing tight junction molecule expression. Thus, the physicians must further investigate the effect of glucocorticoids treatments on implantation.
Authors
- Mehrdad Bakhtiyari (ORCID: https://orcid.org/0000-0001-8633-5378)
- Fatemehsadat Amjadi (ORCID: https://orcid.org/0000-0003-4902-388X)
- Hossein Eyni (ORCID: https://orcid.org/0000-0001-7152-4512)
- Aryan Ayati (ORCID: https://orcid.org/0000-0002-0241-6865)
- Sahar Eghbali
- Mehrdad Ghorbanlou (ORCID: https://orcid.org/0000-0002-5436-0074)
- Mehdi Mehdizadeh (ORCID: https://orcid.org/0000-0002-9268-7318)
- Fatemeh Moradi (ORCID: https://orcid.org/0000-0002-9043-0439)
- Marzieh Ajdary
Institutions
- Iran University of Medical Sciences (IR)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- JBRA
- Published
- 2025-01-01
- DOI
- https://doi.org/10.5935/1518-0557.20250027
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.00