Subclinical Myocardial Involvement Evaluated by Cardiac Magnetic Resonance Imaging in a Patient with Anti-Ro52/SS-A Antibody-positive Sjögren's Disease Complicated with Polymyositis

A 52-year-old woman with myalgia, anti-aminoacyl tRNA synthetase, anti-SS-A/Ro52 antibody positivity, and elevated creatine kinase levels was admitted to our hospital. She was diagnosed with Sjögren's disease (SjD) complicated by polymyositis (PM). No chest symptoms were observed. Although her electrocardiogram and echocardiogram findings were normal, cardiac magnetic resonance imaging (CMRI) revealed myocardial edema and fibrosis with late gadolinium enhancement, elevated extracellular volume, and elevated T2 values. After treatment with prednisolone, the myalgia and CMRI abnormalities improved. This case suggests that CMRI may be useful for the detection and treatment of subclinical myocardial damage in patients with SjD complicated by PM.

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Journal
Internal Medicine
Published
2025-07-16
DOI
https://doi.org/10.2169/internalmedicine.5500-25
Primary Topic
Inflammatory Myopathies and Dermatomyositis
Type
article
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article

Subclinical Myocardial Involvement Evaluated by Cardiac Magnetic Resonance Imaging in a Patient with Anti-Ro52/SS-A Antibody-positive Sjögren's Disease Complicated with Polymyositis

Masashi Uchikawa, Yosuke Nagasawa, Shinya Asatani, Kiminobu Sugito et al.
Internal Medicine
Inflammatory Myopathies and Dermatomyositis
article

Subclinical Myocardial Involvement Evaluated by Cardiac Magnetic Resonance Imaging in a Patient with Anti-Ro52/SS-A Antibody-positive Sjögren's Disease Complicated with Polymyositis

Masashi Uchikawa, Yosuke Nagasawa, Shinya Asatani, Kiminobu Sugito, Hitomi Kobayashi, Masako Tsukamoto, Hideki Nakamura, Masahiro Nishihara, Noboru Kitamura, Yasuo Okumura, Hirotake Inomata
article en

Abstract

A 52-year-old woman with myalgia, anti-aminoacyl tRNA synthetase, anti-SS-A/Ro52 antibody positivity, and elevated creatine kinase levels was admitted to our hospital. She was diagnosed with Sjögren's disease (SjD) complicated by polymyositis (PM). No chest symptoms were observed. Although her electrocardiogram and echocardiogram findings were normal, cardiac magnetic resonance imaging (CMRI) revealed myocardial edema and fibrosis with late gadolinium enhancement, elevated extracellular volume, and elevated T2 values. After treatment with prednisolone, the myalgia and CMRI abnormalities improved. This case suggests that CMRI may be useful for the detection and treatment of subclinical myocardial damage in patients with SjD complicated by PM.

Internal MedicineVol. 65(3)
Nihon University (JP)
Good health and well-being
Openalex Percentile: Top 75%
Inflammatory Myopathies and Dermatomyositis
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