[S1PR5 activation or overexpression enhances barrier function of mouse brain microvascular endothelial cells against OGD/R injury by modulating oxidative stress].
S1PR5 activation and overexpression significantly improve cell viability and reduce permeability of a mouse brain microvascular endothelial cell model of OGD/R, the mechanism of which may involve the reduction in ROS production and upregulation of the antioxidant proteins.
Authors
- Zijing Ren
- Peiyang Zhou (ORCID: https://orcid.org/0009-0002-6138-1129)
- Jingxian Wang (ORCID: https://orcid.org/0000-0002-9484-6570)
Institutions
- Xiang Yang No.1 People's Hospital (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-07-20
- DOI
- https://doi.org/10.12122/j.issn.1673-4254.2025.07.11
- Primary Topic
- Heme Oxygenase-1 and Carbon Monoxide
- Type
- article