[Therapeutic mechanism of hederagenin, an active component in <i>Guizhi Fuling</i> Pellets, against cervical cancer in nude mice].
GZFL Pellets inhibit cervical cancer cell growth through its multiple active components that target different pathways. Among these components, hederagenin inhibits tumor cell growth possibly by directly binding to JAK2 protein to inhibit STAT3 phosphorylation.
Authors
- Kunxiang Gong
- Yiran Li (ORCID: https://orcid.org/0000-0002-7348-0143)
- Yi Wang (ORCID: https://orcid.org/0000-0002-8580-3341)
- Wenbo Hao (ORCID: https://orcid.org/0000-0003-3850-6501)
- Lingling Sun
- Yinger Huang (ORCID: https://orcid.org/0000-0002-7609-6120)
- Yinfu Zhu
Institutions
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-07-20
- DOI
- https://doi.org/10.12122/j.issn.1673-4254.2025.07.08
- Primary Topic
- Phytochemistry and Bioactive Compounds
- Type
- article