[The TGF‑β/miR-23a-3p/IRF1 axis mediates immune escape of hepatocellular carcinoma by inhibiting major histocompatibility complex class I].
We reveal a novel immune escape mechanism of HCC, in which TGF‑β attenuates T cell-mediated antitumor immunity by suppressing MHC-I expression through the miR-23a-3p/IRF1 signaling axis.
Authors
- Yingyan Yu (ORCID: https://orcid.org/0000-0002-3585-3252)
- Xueyi Song (ORCID: https://orcid.org/0000-0002-3274-0543)
- Qianqian Shao (ORCID: https://orcid.org/0000-0001-9937-0631)
- Xiaolong Tang (ORCID: https://orcid.org/0000-0001-9229-6424)
- Yang Liu (ORCID: https://orcid.org/0000-0002-5636-030X)
- Li Tu (ORCID: https://orcid.org/0000-0003-3307-5554)
Institutions
- Anhui University of Science and Technology (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-07-20
- DOI
- https://doi.org/10.12122/j.issn.1673-4254.2025.07.06
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article