Protracted SARS-CoV-2 Infection in B-cell Depleted Patients: Immunologic and Viral Characteristics and Response to Dual and Extended Antiviral Therapy
Dual/extended antiviral therapy with nirmatrelvir/r and remdesivir can be effective for protracted SARS-CoV-2 infection in B-cell-depleted patients who fail antiviral monotherapy, despite persistently blunted humoral immune responses. Additionally, immunocompromised hosts are at risk of both protracted infection and early re-infection, which can be differentiated by viral sequencing.
Authors
- Nicolas C. Issa (ORCID: https://orcid.org/0000-0002-6596-0518)
- Hannah Levine
- Rinki Deo
- Muneerah M Aleissa (ORCID: https://orcid.org/0000-0003-2167-5122)
- Meghan A. Baker (ORCID: https://orcid.org/0000-0002-6724-5841)
- Zoe Swank (ORCID: https://orcid.org/0000-0001-8825-0335)
- Ella Borberg (ORCID: https://orcid.org/0000-0002-7154-6225)
- Jonathan Z. Li (ORCID: https://orcid.org/0000-0001-9914-9662)
- Pritha Sen (ORCID: https://orcid.org/0000-0002-9102-4045)
- Hayden S Andrews (ORCID: https://orcid.org/0009-0009-3777-9744)
- Amy C Sherman (ORCID: https://orcid.org/0000-0002-6075-3990)
- Kenneth J. Friedman (ORCID: https://orcid.org/0000-0001-5735-5855)
- Scott Dryden‐Peterson (ORCID: https://orcid.org/0000-0002-8487-9731)
- Ann E. Woolley (ORCID: https://orcid.org/0000-0002-2810-1618)
- Jessica S Little (ORCID: https://orcid.org/0000-0001-8093-5647)
- Manish C. Choudhary (ORCID: https://orcid.org/0000-0002-3192-7840)
- Cameron T. Nutt
- Lisa A. Cosimi (ORCID: https://orcid.org/0000-0002-5269-1881)
- David R. Walt (ORCID: https://orcid.org/0000-0002-5524-7348)
- Lindsey Robert Baden (ORCID: https://orcid.org/0009-0004-1752-1926)
- Urwah Kanwal
- Xiaofang Li (ORCID: https://orcid.org/0000-0002-5148-2922)
- Gregory E. Edelstein
- Anna Piermattei
- Aidan Eustace
Institutions
- Princess Nourah bint Abdulrahman University (SA)
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Dana-Farber Cancer Institute (US)
- Inspire Institute (US)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1093/cid/ciaf383
- Citations
- 4
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 5.58