Thymic Microenvironment Remodeling in Cancer Cachexia as a Determinant of Checkpoint Inhibitor Efficacy and Toxicity
Cancer cachexia disrupts mFbs maturity, affecting T cell negative selection and expanding the TCR repertoire against tissue-restricted antigens. This might mediate the adverse and favourable effects of ICIs as anticancer treatments.
Authors
- Yan‐Fang Xing
- Runkai Huang
- Qintai Yang (ORCID: https://orcid.org/0000-0003-3377-737X)
- L. Peng
- Xiu‐Qing Pang
- Xiaotong Lv
- Xing Li (ORCID: https://orcid.org/0000-0001-9145-4769)
- Zhaohui Shi (ORCID: https://orcid.org/0000-0002-3561-1894)
- Wěi Li (ORCID: https://orcid.org/0000-0003-3964-5546)
- Xiang-yuan Wu
Institutions
- Sun Yat-sen University (CN)
- Third Affiliated Hospital of Guangzhou Medical University (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1002/jcsm.13874
- Citations
- 2
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- National Natural Science Foundation of China