Decreased Microbiota-Driven Tyrosine Metabolism Is Associated With Symptomatic COVID-19 in Children.
Our findings highlight a relationship between the ability of the gut microbiota to metabolize tyrosine and the development of COVID-19 symptoms in children. More generally, our study suggests that the gut microbiota may help protect against more severe forms of COVID-19, potentially by modulating IFN-α.
Authors
- Neeraj K. Surana (ORCID: https://orcid.org/0000-0002-9544-2551)
- Jillian H. Hurst (ORCID: https://orcid.org/0000-0001-5079-9920)
- Danting Jiang
- Ghada Mohamed (ORCID: https://orcid.org/0000-0002-5831-4083)
- Matthew S. Kelly (ORCID: https://orcid.org/0000-0001-8819-2315)
- Jatin Roper (ORCID: https://orcid.org/0000-0002-8851-1352)
Institutions
- Duke University (US)
Publication Details
- Journal
- PubMed
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1093/infdis/jiaf325
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00