MiRNA-29b accelerates the PDGF in exosomes and stimulates hepatic stellate cells to promote liver fibrosis in biliary atresia
Our study showed that miRNA-29b was highly expressed in peripheral blood exosomes and that PDGFA was highly expressed in liver tissues in children with BA. Exosomes overexpressing miRNA-29b caused hypomethylation of the DNA promoter region of PDGFA in hepatic stellate cells, promoted the high expression of PDGFA, activated hepatic stellate cells, and participated in BA-associated liver fibrosis, elucidating the pathogenesis of BA.
Authors
- Xiaodong Liao (ORCID: https://orcid.org/0000-0001-9230-5220)
- Chengyan Tang
- Teng Zhou (ORCID: https://orcid.org/0000-0002-7709-0265)
- Zhu Jin (ORCID: https://orcid.org/0000-0002-1268-8901)
- Wankang Zhou
- Daiwei Zhu
- Yuanmei Liu
- Qing Du
- Zebing Zheng (ORCID: https://orcid.org/0000-0003-3392-7104)
- Kaizhi Zhang
- Xiangang Xiong
- Xingrong Xia
- Xiaohuan Zhao
- Rui Liu (ORCID: https://orcid.org/0000-0002-0549-3532)
- Yuan Gong
- Lu Huang
Institutions
- Zunyi Medical University (CN)
- First People’s Hospital of Zunyi (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1186/s40001-025-02731-z
- Citations
- 1
- Primary Topic
- Pediatric Hepatobiliary Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- National Natural Science Foundation of China