Methadone and the Kidney: Dissecting Gender Differences in Inflammation and Oxidative Stress Responses
Prolonged methadone therapy exerts a nephrotoxic effect through the activation of oxidative stress and inflammatory pathways, with male rats displaying greater renal pathology and dysfunction, potentially attributed to diminished antioxidant defenses.
Authors
- Kambiz Kosari (ORCID: https://orcid.org/0000-0002-2631-4054)
- Zoya Tahergorabi (ORCID: https://orcid.org/0000-0002-9915-256X)
- Hamid Najafipour (ORCID: https://orcid.org/0000-0002-8030-8704)
- Elham Jafari (ORCID: https://orcid.org/0000-0001-9240-9177)
- Saeideh Jafarinejad‐Farsangi (ORCID: https://orcid.org/0000-0003-4694-8174)
- Shadan Saberi (ORCID: https://orcid.org/0000-0003-1987-742X)
Institutions
- Kerman University of Medical Sciences (IR)
- Birjand University of Medical Sciences (IR)
Publication Details
- Journal
- Addiction and Health
- Published
- 2025-05-14
- DOI
- https://doi.org/10.34172/ahj.1625
- Citations
- 1
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 1.29
Funders
- Kerman University of Medical Sciences