Targeting SPHK1 in macrophages remodels the tumor microenvironment and enhances anti‐PD‐1 immunotherapy efficacy in colorectal cancer liver metastasis
Our findings highlighted the role of SPHK1 of TAMs in facilitating CRLM by promoting CD8<sup>+</sup> T cell dysfunction and immunosuppressive microenvironment. Combining SPHK1 blockade with anti-PD-1 therapy may be a promising treatment regimen for patients with CRLM.
Authors
- Yunyan Ling
- Yating Hu (ORCID: https://orcid.org/0000-0003-2590-7066)
- Zhanqiao Zhang
- Yuan Fang (ORCID: https://orcid.org/0000-0003-0483-2237)
- Junying Qian
- Dehua Wu (ORCID: https://orcid.org/0000-0003-0560-0016)
- Zhiyong Shen (ORCID: https://orcid.org/0000-0003-4950-2434)
- Yizhi Zhan (ORCID: https://orcid.org/0000-0002-5079-6129)
- Guoxin Li (ORCID: https://orcid.org/0000-0003-2773-7048)
- Yongsheng Li (ORCID: https://orcid.org/0000-0002-6069-0862)
- XU Jin-song
- Haijun Deng (ORCID: https://orcid.org/0000-0003-4632-2702)
Institutions
- Key Laboratory of Guangdong Province (CN)
- Nanfang Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Cancer Communications
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1002/cac2.70047
- Citations
- 9
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 7.18
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation