Bioinformatics analysis and experimental studies reveal KPNA2 as a novel biomarker of hepatocellular carcinoma progression and telomere maintenance
This study identified eight TM-related hub genes with prognostic significance in HCC and established a novel TM-related gene signature. Furthermore, we validated KPNA2 as a key regulator of telomere maintenance and tumor progression in HCC, suggesting it as a potential therapeutic target for improving clinical management of HCC.
Authors
- Wenjie Zhang (ORCID: https://orcid.org/0000-0001-6572-2600)
- Yong Wang (ORCID: https://orcid.org/0000-0003-0448-9619)
- Ke Ding (ORCID: https://orcid.org/0000-0001-6830-4578)
- Beicheng Sun
- Lei Liu (ORCID: https://orcid.org/0000-0002-4604-4629)
Institutions
- Anhui Jianzhu University (CN)
- Anhui Medical University (CN)
- Hefei University (CN)
- Nanjing Drum Tower Hospital (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Immune Regulation (United Kingdom) (GB)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1186/s40001-025-02866-z
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Anhui Provincial Department of Education
- National Science and Technology Major Project