H2A.X N-terminal acetylation is a newly identified NAA40-mediated modification that is responsive to UV irradiation
Our findings identify H2A.X as a novel bona fide substrate of NAA40. Moreover, the responsiveness of H2A.X N-terminal acetylation to UV-induced DNA damage indicates that this is a dynamic modification with potential biological functions.
Authors
- Costas Koufaris (ORCID: https://orcid.org/0000-0002-1222-5130)
- Christina Demetriadou (ORCID: https://orcid.org/0009-0000-6369-3260)
- Ariel Klavaris
- Antonis Kirmizis (ORCID: https://orcid.org/0000-0002-3748-8711)
- Tiziana Bonaldi (ORCID: https://orcid.org/0000-0003-3556-1265)
- Nikolas Dietis (ORCID: https://orcid.org/0000-0002-8365-3837)
- Roberta Noberini (ORCID: https://orcid.org/0000-0002-7267-1079)
- Maria Kouma
- Alessandro Ghiringhelli
Institutions
- Cyprus Institute (CY)
- University of Nicosia (CY)
- University of Milan (IT)
- University of Cyprus (CY)
- Cyprus Institute of Neurology and Genetics (CY)
- European Institute of Oncology (IT)
Publication Details
- Journal
- Epigenetics & Chromatin
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1186/s13072-025-00608-3
- Citations
- 2
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 2.09