Tanshinone IIA alleviates liver fibrosis by suppressing hepatic stellate cell proliferation via ERK/cyclin D1/p-Smad3L signaling axis.
Tan IIA may improve LF by regulating the signaling axis of ERK/cyclin D1/p-Smad3L, thereby blocking activated HSCs in the G1 phase and inhibiting their proliferation.
Authors
- Mian Wu (ORCID: https://orcid.org/0000-0002-2714-0500)
- Mingze Sun
- Zhiyuan Hao (ORCID: https://orcid.org/0000-0002-7773-0656)
- Wenjing Liao (ORCID: https://orcid.org/0000-0003-2309-3839)
- Meng Fang (ORCID: https://orcid.org/0000-0002-4122-1518)
- Xiaoman Zhou (ORCID: https://orcid.org/0000-0002-0270-2159)
- Chen‐Fei Liu (ORCID: https://orcid.org/0000-0002-3564-0812)
- Fang Wu (ORCID: https://orcid.org/0000-0003-3682-1022)
- Jinglei Wu
- Yuwei Liu (ORCID: https://orcid.org/0000-0002-1482-4858)
- Rui Ye
Institutions
- Jianghan University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-01-01
- DOI
- https://doi.org/10.22038/ijbms.2025.83092.17962
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00