Prognostic Implications of MDM2 and CDK4 Co-amplification in Liposarcoma: Insights from FISH analysis for Translational Oncology
MDM2 amplification was more consistent and quantitatively higher than CDK4, supporting its central role in tumourigenesis. While MDM2/CDK4 co-amplification was associated with poorer outcomes, it lacked independent prognostic value, reflecting the potential influence of other clinical variables. Nevertheless, co-amplification may hold clinical relevance in identifying high-risk liposarcoma subgroups.
Authors
- Sharifah Emilia Tuan Sharif (ORCID: https://orcid.org/0000-0002-0343-4205)
- Sarimah Abdullah (ORCID: https://orcid.org/0000-0002-7966-5966)
- Josmi James (ORCID: https://orcid.org/0009-0001-6465-6135)
- Sahran Yahaya (ORCID: https://orcid.org/0000-0001-9469-4231)
- Aidy Irman Yajid (ORCID: https://orcid.org/0000-0001-5058-2051)
Institutions
- Universiti Sains Malaysia (MY)
- Hospital Universiti Sains Malaysia (MY)
Publication Details
- Journal
- Clinical & Translational Oncology
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1007/s12094-025-03989-9
- Citations
- 1
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Universiti Sains Malaysia