Isolated Anastomotic Ulcers Are Associated with a Higher Long-Term Risk for Postoperative Recurrence and a Differential Mucosa-Associated Microbiome Composition in Patients with Crohn’s Disease Following Ileocolic Resection
IAUs in CD patients with otherwise healthy neo-TI at first postoperative ileocolonoscopy are associated with long-term POR. In addition, a differential mucosa-associated microbiome composition was observed in patients with IAUs, specifically the proteobacteria Klebsiella, suggesting that putative taxa are related to these lesions. Further validation studies in larger cohorts, along with mechanistic studies, are still required.
Authors
- Mark S. Silverberg (ORCID: https://orcid.org/0000-0002-9534-1419)
- Williams Turpin (ORCID: https://orcid.org/0000-0001-9364-5868)
- Haim Leibovitzh (ORCID: https://orcid.org/0000-0002-4172-6903)
- Pablo A. Olivera (ORCID: https://orcid.org/0000-0002-2740-6102)
- Joanne M. Stempak (ORCID: https://orcid.org/0009-0001-6510-8608)
- Cristian Hernández-Rocha (ORCID: https://orcid.org/0000-0001-9018-4242)
- Michiel T. Bak (ORCID: https://orcid.org/0000-0001-8515-425X)
- Raquel Milgrom
- Sun-Ho Lee (ORCID: https://orcid.org/0000-0003-0344-0047)
- Krzysztof Borowski (ORCID: https://orcid.org/0000-0003-3517-9189)
Institutions
- Mount Sinai Hospital (CA)
- Lunenfeld-Tanenbaum Research Institute (CA)
- Canada Research Chairs (CA)
- Erasmus MC (NL)
- Sinai Health System (CA)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Inflammatory Bowel Diseases
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1093/ibd/izaf147
- Citations
- 1
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases