Amantadine reduces sepsis-induced brain injury via NLRP3/caspase-1 inflammasome activation.
The pathophysiology of brain damage due to systemic inflammation is complex. Our findings suggest that amantadine reduces neuronal injury in the brain by alleviating oxidative stress and inflammation. Notably, amantadine's efficacy appears to extend beyond NMDA receptors, implicating involvement in alternative pathways, such as Cas-1 activation by the NLRP3 inflammasome.
Authors
- Muhammet Yusuf Tepebaşı (ORCID: https://orcid.org/0000-0002-1087-4874)
- Mustafa Soner Özcan (ORCID: https://orcid.org/0000-0003-0385-2308)
- Halil Aşçı (ORCID: https://orcid.org/0000-0002-1545-035X)
- Pınar Karabacak (ORCID: https://orcid.org/0000-0002-6210-5962)
- Rümeysa Taner (ORCID: https://orcid.org/0000-0002-2845-3744)
- İlter İlhan (ORCID: https://orcid.org/0000-0003-3739-9580)
- Melih Arlıoğlu (ORCID: https://orcid.org/0009-0009-4356-5857)
- Ahmet Bi̇ndal (ORCID: https://orcid.org/0000-0002-1971-6856)
Institutions
- Süleyman Demirel Üniversitesi (TR)
- Suleyman Demirel University (KZ)
Publication Details
- Journal
- PubMed
- Published
- 2025-01-01
- DOI
- https://doi.org/10.22038/ijbms.2025.81436.17626
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00