Mirikizumab Efficacy in Ulcerative Colitis: Association With Pretreatment Geboes Score Features in a Case Series
Lay Summary We explored mirikizumab efficacy in ulcerative colitis using pretreatment histological findings and 24-week post-treatment initiation endoscopic activity. Patients with epithelial neutrophil infiltration responded well, while those lacking lamina propria eosinophils did not, suggesting predictive roles for specific Geboes Score features.
Authors
- Kei Onishi (ORCID: https://orcid.org/0009-0002-0976-2979)
- Toru Usui (ORCID: https://orcid.org/0000-0002-9536-9868)
- Kozue Kanemitsu‐Okada (ORCID: https://orcid.org/0009-0005-6488-9616)
- Hideko Ohama (ORCID: https://orcid.org/0000-0002-1882-824X)
- Shogo Kitahata (ORCID: https://orcid.org/0000-0003-2133-6569)
- Eiji Tsubouchi (ORCID: https://orcid.org/0009-0000-0669-4398)
- Yoichi Hiasa (ORCID: https://orcid.org/0000-0003-4117-339X)
- Atsushi Hiraoka (ORCID: https://orcid.org/0000-0003-1989-0480)
- Kanako Kato
- Hideki Miyata (ORCID: https://orcid.org/0000-0003-4883-0970)
- Tomoe Kawamura (ORCID: https://orcid.org/0000-0001-6678-8724)
- Junko Matsuoka
- Mai Saito
- Fujimasa Tada (ORCID: https://orcid.org/0009-0007-3964-5876)
- Tomoyuki Ninomiya (ORCID: https://orcid.org/0000-0002-9949-0446)
- Ayaka Nakamura (ORCID: https://orcid.org/0009-0001-3743-8159)
- Taira Kuroda (ORCID: https://orcid.org/0009-0002-1397-1714)
- Yuka Kimura (ORCID: https://orcid.org/0009-0001-6392-6770)
Institutions
- Ehime Prefectural Central Hospital (JP)
- Ehime University (JP)
Publication Details
- Journal
- Inflammatory Bowel Diseases
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1093/ibd/izaf152
- Citations
- 1
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 1.82