Multidose Ondansetron after Emergency Visits in Children with Gastroenteritis
Among children with gastroenteritis-associated vomiting, the provision of ondansetron after an emergency department visit led to lower risk of moderate-to-severe gastroenteritis during the subsequent 7 days than the provision of placebo. (Funded by the Canadian Institutes of Health Research and others; ClinicalTrials.gov number, NCT03851835.).
Authors
- Amy Catherine Plint (ORCID: https://orcid.org/0000-0003-1245-7174)
- Terry Paul Klassen (ORCID: https://orcid.org/0000-0002-5309-7091)
- Martin Offringa (ORCID: https://orcid.org/0000-0002-4402-5299)
- Sarah Williamson-Urquhart
- Jasper Zhongyuan Zhang
- Anna Heath (ORCID: https://orcid.org/0000-0002-7263-4251)
- Darcy Beer
- Yaron Finkelstein (ORCID: https://orcid.org/0000-0002-0947-3571)
- Andrew Dixon (ORCID: https://orcid.org/0000-0003-4722-3298)
- Stephen B. Freedman (ORCID: https://orcid.org/0000-0003-2319-6192)
- Petros Pechlivanoglou (ORCID: https://orcid.org/0000-0001-5090-7936)
- Angela Wallace (ORCID: https://orcid.org/0000-0002-0257-517X)
- Gary Joubert (ORCID: https://orcid.org/0000-0001-6612-6421)
Institutions
- Western University (CA)
- 3M (United States) (US)
- University of Ottawa (CA)
- University of Toronto (CA)
- Children's Hospital of Eastern Ontario (CA)
- London Health Sciences Centre (CA)
- Hospital for Sick Children (CA)
- Alberta Children's Hospital (CA)
- University of Saskatchewan (CA)
- Children's Hospital Research Institute of Manitoba (CA)
- Women and Children’s Health Research Institute (CA)
- Stollery Children's Hospital (CA)
- Alberta Children's Hospital Research Institute
- University College London (GB)
- University of Manitoba (CA)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1056/nejmoa2503596
- Citations
- 4
- Primary Topic
- Viral gastroenteritis research and epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 5.58
Funders
- Alberta Health Services
- Research Manitoba
- Women and Children's Health Research Institute
- CHEO Research Institute
- University of Toronto
- Western University
- Centre hospitalier universitaire Sainte-Justine
- Children's Hospital Research Institute of Manitoba
- Alberta Children's Hospital Research Institute
- Canadian Institutes of Health Research