On-Table Reanimation of a Pediatric Heart from Donation after Circulatory Death

Cardiac allotransplantation is warranted in children with end-stage heart failure or irreparable congenital heart disease. A dearth of organs for transplantation has contributed to long wait-list times and resultant deaths in this population. Donation after circulatory death (DCD) with normothermic regional perfusion has the potential to increase the donor pool by up to 30%. Ethical concerns have limited adoption of this technique in the United States and abroad. Consequently, a method facilitating ex vivo resuscitation of hearts from deceased donors after circulatory death (i.e., DCD hearts) is needed. We describe an on-table reanimation of a pediatric DCD heart transplanted into a 3-month-old recipient. Adverse events are reported.

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Publication Details

Journal
New England Journal of Medicine
Published
2025-07-16
DOI
https://doi.org/10.1056/nejmoa2503487
Citations
11
Primary Topic
Cardiac Arrest and Resuscitation
Type
article
Field-Weighted Citation Impact
24.79
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article

On-Table Reanimation of a Pediatric Heart from Donation after Circulatory Death

Joseph William Turek, Douglas M. Overbey, John A. Kucera
11 citations
New England Journal of Medicine
Cardiac Arrest and Resuscitation
24.79
article

On-Table Reanimation of a Pediatric Heart from Donation after Circulatory Death

Joseph William Turek, Douglas M. Overbey, John A. Kucera
article en
11 citations

Abstract

Cardiac allotransplantation is warranted in children with end-stage heart failure or irreparable congenital heart disease. A dearth of organs for transplantation has contributed to long wait-list times and resultant deaths in this population. Donation after circulatory death (DCD) with normothermic regional perfusion has the potential to increase the donor pool by up to 30%. Ethical concerns have limited adoption of this technique in the United States and abroad. Consequently, a method facilitating ex vivo resuscitation of hearts from deceased donors after circulatory death (i.e., DCD hearts) is needed. We describe an on-table reanimation of a pediatric DCD heart transplanted into a 3-month-old recipient. Adverse events are reported.

New England Journal of MedicineVol. 393(3)
Duke University (US), Duke Children's Hospital & Health Center (US), Duke University Hospital (US)
Openalex Percentile: Top 0%
Cardiac Arrest and Resuscitation
24.79
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