Use of Antiseizure Medications Early in Pregnancy and the Risk of Major Malformations in the Newborn
Results confirm the association between maternal use of valproate, phenobarbital, and topiramate early in pregnancy and a higher risk of major malformations in the infant compared with lamotrigine. However, they do not support meaningful risk elevation for levetiracetam, oxcarbazepine, gabapentin, or zonisamide. Relative risk estimates for lacosamide and pregabalin are still imprecise.
Authors
- Sonia Hernández–Dı́az (ORCID: https://orcid.org/0000-0003-1458-7642)
- Amy Lyons (ORCID: https://orcid.org/0000-0003-3132-0050)
- Susan Conant
- Lewis B. Holmes (ORCID: https://orcid.org/0000-0002-0259-4848)
- P. Emanuela Voinescu (ORCID: https://orcid.org/0000-0001-5216-2018)
- Esther Bui (ORCID: https://orcid.org/0000-0002-5785-9524)
- Hyo Chae Paik (ORCID: https://orcid.org/0000-0001-9309-8235)
- W. Allen Hauser (ORCID: https://orcid.org/0000-0002-5077-654X)
- Deborah G. Hirtz (ORCID: https://orcid.org/0000-0002-6360-6443)
- J. H. Ward
- Mark S. Yerby
- Frances A. High
- Moira Quinn
Institutions
- American International College (US)
- University of Vermont (US)
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Oregon Health & Science University (US)
- University of Toronto (CA)
- Massachusetts General Hospital (US)
- Columbia University (US)
Publication Details
- Journal
- Neurology
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1212/wnl.0000000000213786
- Citations
- 12
- Primary Topic
- Pharmacological Effects and Toxicity Studies
- Type
- article
- Field-Weighted Citation Impact
- 41.93