Antigenic composition of autogenous vaccines against mastitis in dairy goats: variability and optimization

Subclinical and clinical mastitis in goats lead to decreased milk yield, disruptions in the dairy production cycle, and economic losses. At the present stage of veterinary medicine, empirical antibiotic therapy occupies a leading place in the therapy of bacterial diseases. The global trend towards the development of antibiotic resistance in opportunistic bacteria reduces the effectiveness of the trend method and raises the question of finding and updating new methods for the treatment and prevention of bacterial diseases in goats. The study revealed the prevalence of resistance of opportunistic microorganisms to popular antibacterial substances used in the treatment of mastitis in goats. The variability of the composition of etiologically significant opportunistic microorganisms was established and a scheme for optimizing the formation of the composition of antigen producers of autogenous vaccines for the treatment and prevention of mastitis in dairy goats was demonstrated. Using the example of the scheme for optimizing the antigen composition, considering the variability of the mammary gland microbiome in goats from different farms, autogenous vaccines were created and used in a small herd. The study added to the knowledge about the effectiveness of autovaccination for the treatment of mastitis in goats and showed the prospect of further use of an alternative antibiotic therapy method.