Regenerative activity of Ginkgo bilobate (Ginkgo biloba L.) leaf extract against skin burn injury

The article describes the results of studying the possible regenerative activity of Ginkgo biloba L. leaf extract (Ginkgo biloba L.) against the background of burn skin injury. The study was carried out on non-linear male rats with an average weight of 220 grams. Age 6–7 months. The burn injury was simulated under ether narcotic conditions in the interscapular region of the back. Laboratory animals were divided into groups: group I – animals not exposed to burns – intact (n=10); Group II – animals receiving intragastrically distilled water and externally isotonic NaCl solution against the background of a burn injury of the skin (n=10); Group III – animals treated with aloe liniment application and intragastric administration of distilled water (combined administration) (n=10) for 21 days; Group IV – animals receiving applications and intragastric administration (combined administration) of Ginkgo biloba leaf extract (L. Ginkgo) (n=10) for 21 days. Under conditions of burn exposure, pronounced destructive transformations, edematous and inflammatory changes of the skin occurred. Affecting the skin, the burn injury triggered a cascade of pathophysiological reactions at the level of the whole organism. In the course of the study, it was found that daily applications (at a dose of 0,09 mg in terms of polysaccharides) and intragastric administration (at a dose of 50 mg/ kg/day) of Ginkgo bilobate leaf extract on the damaged skin surface for 21 days, starting from the second day after the burn, led to a decrease in edematous and inflammatory changes, a decrease in the destructive surface area by an average of 2 times (p < 2) vs self-reconstituted animals. The use of Aloe liniment initiated morphogenetic processes in the skin aimed at reparative regeneration. The combined administration of Ginkgo bilobate leaf extract led to the relief of the inflammatory process, a decrease in hyperemia and swelling of the tissues, accelerated epithelization, reduced area and restoration of the post-destructive surface of the skin. The regenerative potential of Ginkgo bilobate leaf extract studied in the study against the background of burn skin injury allows us to consider the prospects for developing drugs based on it that have the effect of stimulating tissue repair.