Multimodal neuroimaging unveils basal forebrain-limbic system circuit dysregulation in cognitive impairment with depression: a pathway to early diagnosis and intervention
We identified a neuroinflammatory-cholinergic pathway in the basal forebrain as an early mechanism driving depression-associated cognitive decline. Multimodal imaging revealed distinct spatiotemporal patterns of circuit dysregulation, suggesting neuroinflammation and iron deposition precede structural degeneration. These findings position the basal forebrain-limbic system circuit as a therapeutic target and provide actionable biomarkers for early intervention in AD with depressive symptoms.
Authors
- Yongjun Tan (ORCID: https://orcid.org/0000-0002-0765-108X)
- Zhongfeng Xie
- Ling Yue (ORCID: https://orcid.org/0000-0001-6476-0189)
- Mengling Tao (ORCID: https://orcid.org/0009-0007-1947-5208)
- Shifu Xiao (ORCID: https://orcid.org/0000-0002-4721-9646)
- Pei‐Ying Chen (ORCID: https://orcid.org/0000-0003-2288-3927)
- Xiaowen Xu
- Yongsheng Xiang
- Peijun Wang (ORCID: https://orcid.org/0000-0002-1456-1269)
- Yingying Liu
- Xiereniguli Anayiti
Institutions
- Tongji University (CN)
- Shanghai Mental Health Center (CN)
Publication Details
- Journal
- The Journal of Prevention of Alzheimer s Disease
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1016/j.tjpad.2025.100298
- Citations
- 1
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.43