Single-cell spatial analysis with Xenium reveals anti-tumour responses of CXCL13 + T and CXCL9+ cells after radiotherapy combined with anti-PD-L1 therapy
These findings suggest potential advancements in developing new treatments to improve posttreatment immune responses and address resistance challenges.
Authors
- Junko Zenkoh (ORCID: https://orcid.org/0009-0004-2371-3641)
- Shun‐Ichiro Kageyama (ORCID: https://orcid.org/0000-0002-6072-0144)
- Shunsuke A. Sakai (ORCID: https://orcid.org/0009-0002-3740-6795)
- Junichi Soh (ORCID: https://orcid.org/0000-0001-8532-7915)
- Katsuya Tsuchihara (ORCID: https://orcid.org/0000-0001-7507-2349)
- Yuka Nakamura (ORCID: https://orcid.org/0009-0007-2030-8968)
- Keiju Aokage (ORCID: https://orcid.org/0000-0003-3193-9646)
- Hidenari Hirata (ORCID: https://orcid.org/0000-0003-3130-6857)
- Kotaro Nomura (ORCID: https://orcid.org/0009-0009-1487-6533)
- Hidekazu Oyoshi (ORCID: https://orcid.org/0000-0002-5600-0312)
- Masaki Nakamura (ORCID: https://orcid.org/0000-0002-4431-8892)
- Masahiro Tsuboi (ORCID: https://orcid.org/0000-0003-3031-5807)
- Genichiro Ishii (ORCID: https://orcid.org/0000-0001-8637-3323)
- Takeshi Kuwata (ORCID: https://orcid.org/0000-0003-0044-953X)
- Ayako Suzuki (ORCID: https://orcid.org/0000-0003-1824-1067)
- Atsushi Motegi (ORCID: https://orcid.org/0000-0001-5231-6443)
- Akira Hamada (ORCID: https://orcid.org/0000-0003-1689-9447)
- Yutaka Suzuki (ORCID: https://orcid.org/0000-0001-7504-9464)
- Tetsuro Taki (ORCID: https://orcid.org/0000-0001-8654-6896)
- Hidehiro Hojo
- Tetsuo Akimoto (ORCID: https://orcid.org/0000-0003-0881-1345)
- Tetsuya Mitsudomi (ORCID: https://orcid.org/0000-0001-9860-8505)
- Motohiro Kojima (ORCID: https://orcid.org/0000-0002-6150-6545)
- Riu Yamashita
Institutions
- Ube Frontier University (JP)
- Kyoto Prefectural University of Medicine (JP)
- Chiba Cancer Center (JP)
- National Cancer Center Hospital East (JP)
- The University of Tokyo (JP)
- Kindai University (JP)
Publication Details
- Journal
- British Journal of Cancer
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1038/s41416-025-03088-0
- Citations
- 6
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 6.27
Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Japan Society for the Promotion of Science
- Japan Science and Technology Agency