Exosomes derived from platelet-rich plasma alleviate synovial inflammation by enhancing synovial lymphatic function
This research is the first to reveal that PRP-Exos alleviate pain behaviors and synovial inflammation in DMM mice through activation of the PI3K/Akt signaling pathway in LECs, thereby enhancing synovial lymphatic function and promoting the clearance of inflammatory cells and associated cytokines. These findings offer a novel theoretical foundation for the treatment of synovial inflammation and other inflammation-associated disorders.
Authors
- Bin Zhang (ORCID: https://orcid.org/0000-0002-7097-2011)
- Bo Liao (ORCID: https://orcid.org/0000-0002-6596-2302)
- Po‐Ren Teng
- Kaiting Li (ORCID: https://orcid.org/0000-0001-9155-0240)
- Mengtong Guan (ORCID: https://orcid.org/0009-0007-0695-586X)
- Ying Zhu (ORCID: https://orcid.org/0000-0003-3707-5834)
- Xiaoyu Han (ORCID: https://orcid.org/0000-0002-8617-8664)
- Yajuan Niu
- Dingqun Bai (ORCID: https://orcid.org/0000-0002-6727-4634)
- Han Wang (ORCID: https://orcid.org/0000-0002-1123-4086)
- Weiwei Yi (ORCID: https://orcid.org/0000-0003-4602-4553)
- Xiaoliang Yang
- Yu Tian (ORCID: https://orcid.org/0000-0001-5338-8035)
- Liang Kuang
Institutions
- Army Medical University (CN)
- Daping Hospital (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1186/s12951-025-03591-9
- Citations
- 4
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Chongqing
- Centre Scientifique et Technique du Bâtiment