Pathophysiological mechanisms in severe preeclampsia: role of upregulated proteins in blood pressure, extracellular matrix and immunity
These findings offer valuable insights into the different pathophysiological mechanisms underlying the two subgroups of PE. The upregulated proteins in PE+ (AMBP, VTN, CLU, F2, PZP, APCS, and HBB) play key roles in regulating blood pressure, modulating the extracellular matrix and influencing immune responses. Overall, this research deepens our understanding of the complexity and clinical significance of PE.
Authors
- Bruno César Rossini (ORCID: https://orcid.org/0000-0002-5685-9610)
- Valéria C. Sandrim (ORCID: https://orcid.org/0000-0002-6168-7470)
- Lucilene Delazari dos Santos (ORCID: https://orcid.org/0000-0001-5832-1825)
- Caroline C. Pinto-Souza (ORCID: https://orcid.org/0000-0002-7135-9550)
- Ricardo de Carvalho Cavalli (ORCID: https://orcid.org/0000-0001-5010-4914)
- Julyane N. S. Kaihara (ORCID: https://orcid.org/0000-0003-4881-8488)
Institutions
- Universidade de Ribeirão Preto (BR)
- Universidade Estadual Paulista (Unesp) (BR)
Publication Details
- Journal
- Revista Brasileira Ginecologia e Obstetrícia
- Published
- 2025-01-01
- DOI
- https://doi.org/10.61622/rbgo/2025rbgo54
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico