Structure of Comorbidities and Causes of Death in Patients with Atrial Fibrillation and Chronic Obstructive Pulmonary Disease

<b>Background/Objectives</b>: The aim of this study was to assess the structure of comorbidities, the reasons for seeking medical care, and the main causes of fatal outcomes in patients with atrial fibrillation (AF) and chronic obstructive pulmonary disease (COPD). <b>Methods</b>: A retrospective analysis of 40,772 electronic medical records in the database of the medical information system with the analysis of medical care requests and causes of fatal outcomes over a 4-year period (from 1 February 2021 to 1 February 2025) was performed. The study participants were divided into three groups. The first group included 1247 participants with AF and COPD (AF + COPD group). The second group included 25,474 patients with AF and without COPD (AF group), and the third group included 14051 patients with COPD and without AF (COPD group). <b>Results</b>: Patients with AF + COPD compared to patients with AF alone and COPD alone were more likely to have anemia (5.21% vs. 3.64% and 2.8%, respectively), pulmonary embolism (2.0% vs. 0.52% and 0.46% respectively), type 2 diabetes mellitus (28.2% vs. 22.7% and 14.32%), obesity (24.86% vs. 22.2% and 17.72%), chronic ischemic heart disease (89.25% vs. 78.69% and 49.31%), and chronic heart failure (16.76% vs. 9.47% and 3.22%). In addition, patients with AF + COPD demonstrated the highest mortality among all groups. <b>Conclusions</b>: Patients who have both AF and COPD have more comorbidities, seek medical care more frequently, and have worse survival compared with patients with only AF or only COPD.