Wuse-oil Compound 03 mitigates radiation-induced oral mucositis by modulating oral microbiota to mediate TLR4/NF-κB pathway and inhibit M1 macrophage polarization
WC03 preserves the oral microbiota in RIOM rats. Our findings demonstrate for the first time that Emodin acts as a key active compound by inhibiting the TLR4/NF-κB pathway and M1 macrophage polarization, thus alleviating RIOM symptoms.
Authors
- Zihan Jin (ORCID: https://orcid.org/0000-0003-4941-2703)
- Rong Huang (ORCID: https://orcid.org/0000-0002-7850-6736)
- Dongmei Chen (ORCID: https://orcid.org/0000-0002-3456-8492)
- Jialu Liu (ORCID: https://orcid.org/0000-0002-2956-7436)
- Feng Teng (ORCID: https://orcid.org/0000-0003-0391-0723)
- Li Ma (ORCID: https://orcid.org/0000-0003-4677-5533)
- Feng Ye (ORCID: https://orcid.org/0000-0002-9159-7767)
- Dong Li (ORCID: https://orcid.org/0000-0002-4735-7520)
- Chen Chen (ORCID: https://orcid.org/0009-0009-6806-7117)
- Yanni Lou (ORCID: https://orcid.org/0000-0003-3181-494X)
- Liqun Jia
- Tian Gu (ORCID: https://orcid.org/0000-0002-2732-4991)
- Jingyi Long
Institutions
- Queen Mary University of London (GB)
- Beijing University of Chinese Medicine (CN)
- Peking University (CN)
- China-Japan Friendship Hospital (CN)
- Peking University Cancer Hospital (CN)
- Hangzhou Hospital of Traditional Chinese Medicine (CN)
- Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1016/j.phymed.2025.157083
- Citations
- 1
- Primary Topic
- Oral health in cancer treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.52