Prognostic Implications of Splenomegaly in BCMA-Directed CAR T-Cell Therapy for Relapsed Myeloma
Spleen size may serve as a promising prognostic marker in CAR T-cell therapy for RRMM patients, providing a simple and readily accessible tool for enhancing risk stratification. This finding could inform monitoring strategies and optimize healthcare resource management for these patients.
Authors
- Hans‐Jonas Meyer (ORCID: https://orcid.org/0000-0001-8489-706X)
- Klaus Hans Metzeler (ORCID: https://orcid.org/0000-0003-3920-7490)
- Carmen Herling
- Marco Herling (ORCID: https://orcid.org/0000-0001-7473-7476)
- Nora Grieb (ORCID: https://orcid.org/0009-0003-4754-6887)
- Vladan Vučinić (ORCID: https://orcid.org/0000-0002-8398-285X)
- Kristin Reiche (ORCID: https://orcid.org/0000-0002-4452-4872)
- Song Yau Wang
- Madlen Jentzsch (ORCID: https://orcid.org/0000-0002-2270-0804)
- Simone Heyn
- Timm Denecke (ORCID: https://orcid.org/0000-0003-3313-3208)
- Patrick Born (ORCID: https://orcid.org/0009-0002-8463-5179)
- Uwe Platzbecker (ORCID: https://orcid.org/0000-0003-1863-3239)
- Thomas Neumuth (ORCID: https://orcid.org/0000-0001-6999-5024)
- Heike Weidner (ORCID: https://orcid.org/0009-0001-6045-3349)
- Maximilian Merz (ORCID: https://orcid.org/0000-0002-2805-5973)
- David Fandrei (ORCID: https://orcid.org/0009-0006-4014-6030)
- Maximilian Ferle
- Luise Fischer (ORCID: https://orcid.org/0009-0006-3619-2958)
- J. L. Ader
- Georg‐Nikolaus Franke (ORCID: https://orcid.org/0000-0001-8239-002X)
- Veronika Sotikova
- Thomas C. Wiemers (ORCID: https://orcid.org/0009-0000-2053-3857)
Institutions
- University Hospital Leipzig (DE)
- Fraunhofer Institute for Cell Therapy and Immunology (DE)
- Center for Systems Biology Dresden (DE)
- Technische Universität Dresden (DE)
- Leipzig University (DE)
Publication Details
- Journal
- Transplantation and Cellular Therapy
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1016/j.jtct.2025.07.003
- Citations
- 1
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 1.05