Differential Control of Growth and Identity by HNF4α Isoforms in Pancreatic Ductal Adenocarcinoma
HNF4α isoforms exhibit heterogeneous expression in PDAC and have distinct effects on proliferation and gene expression, including markers of clinically relevant molecular subtypes.
Authors
- Kajsa E. Affolter (ORCID: https://orcid.org/0000-0002-1703-0535)
- Eric L. Snyder (ORCID: https://orcid.org/0000-0003-3591-3195)
- Richard A. Moffitt (ORCID: https://orcid.org/0000-0003-2723-5902)
- Acramul Haque Kabir (ORCID: https://orcid.org/0000-0002-4899-5786)
- Chris Stubben (ORCID: https://orcid.org/0000-0002-3390-4888)
- Emily R. Wilson
- Pengshu Fang (ORCID: https://orcid.org/0000-0002-4645-6869)
- Walter A. Orellana (ORCID: https://orcid.org/0000-0003-4109-021X)
- Sydney N. Larsen
- Xiaoyang Zhang (ORCID: https://orcid.org/0000-0002-0031-0290)
- Margaret A Hall (ORCID: https://orcid.org/0000-0002-6263-440X)
Institutions
- Emory University (US)
- University of Utah (US)
- Huntsman Cancer Institute (US)
- University of Utah Health Care (US)
Publication Details
- Journal
- Molecular Cancer Research
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1158/1541-7786.mcr-25-0175
- Citations
- 2
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- National Cancer Institute