An anti-idiotypic single domain antibody as Cry2Aa toxin mimotope and analysis of its binding region through molecular docking
The findings from this study indicate that the isolated Cry2Aa anti-idiotypic sdAb mimics the molecular interaction pattern of the Cry2Aa toxin with its midgut receptors. The anti-idiotypic sdAb offers new potential for developing novel insect control strategies.
Authors
- Manman Lin
- Guangjie Han (ORCID: https://orcid.org/0000-0002-3920-9413)
- Xia Yang (ORCID: https://orcid.org/0000-0002-8142-5857)
- Yurong Lu
- Jian Xu (ORCID: https://orcid.org/0000-0003-1988-7337)
- Qin Liu (ORCID: https://orcid.org/0000-0001-9288-3282)
- Chuanming Li (ORCID: https://orcid.org/0000-0002-4006-9411)
- Johnson Lin (ORCID: https://orcid.org/0000-0002-9621-9343)
- Yuan Liu (ORCID: https://orcid.org/0000-0001-6773-4605)
- Lixin Huang (ORCID: https://orcid.org/0000-0002-8507-1910)
- Xianjin Liu (ORCID: https://orcid.org/0000-0002-6316-7559)
- Nan Zhang (ORCID: https://orcid.org/0009-0006-0411-738X)
Institutions
- National Agricultural Research Institute (PG)
- Jiangsu Academy of Agricultural Sciences (CN)
- University of KwaZulu-Natal (ZA)
Publication Details
- Journal
- BMC Biotechnology
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1186/s12896-025-01009-w
- Primary Topic
- Animal Virus Infections Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jiangsu Agricultural Science and Technology Innovation Fund
- National Natural Science Foundation of China
- National Key Research and Development Program of China