Downstream interaction by glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide agonism is required for synergistic effects on body weight
As with selective GLP1RA, the actions of dual GLP1RA/GIPA appear to be dependent on the dorsal vagal complex for their action, probably most importantly by gaining access through the area postrema. Downstream targets include the central amygdala where signals following dual receptor agonism interact. Specifically, Nts<sup>CeA</sup> neurons are required for the full synergistic effect of dual receptor agonism on body weight.
Authors
- Alessia Costa (ORCID: https://orcid.org/0000-0002-3693-3019)
- Simon M. Luckman (ORCID: https://orcid.org/0000-0001-5318-5473)
- Claire H. Feetham
- Jenna Hunter (ORCID: https://orcid.org/0000-0002-4119-1136)
- Tamer Coşkun (ORCID: https://orcid.org/0000-0002-2481-133X)
- Minrong Ai (ORCID: https://orcid.org/0000-0002-2531-7958)
- Isabella Culotta (ORCID: https://orcid.org/0000-0001-5861-859X)
- Paul J. Emmerson
- Giuseppe D’Agostino (ORCID: https://orcid.org/0000-0002-3502-4251)
Institutions
- Eli Lilly (United States) (US)
- University of Manchester (GB)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1016/j.molmet.2025.102214
- Citations
- 2
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.33