Diagnostic value of the correlation between urinary MDM2 and podocyte mitotic catastrophe in diabetic kidney disease
We observed that PMC and elevated urinary MDM2/Cr levels emerged early in DKD. Additionally, we developed a diagnostic panel combining urinary MDM2/Cr and SP/Cr, which might serve as a predictive tool for early DKD diagnosis and prevention.
Authors
- Guo-Xiu Li (ORCID: https://orcid.org/0000-0003-0831-0516)
- Wenqi Gan (ORCID: https://orcid.org/0000-0002-7172-4992)
- Li Xu (ORCID: https://orcid.org/0009-0000-2900-2040)
- Qiuling Fan (ORCID: https://orcid.org/0000-0003-2598-6075)
- Jianing Wang (ORCID: https://orcid.org/0000-0003-2690-3438)
- Peihao Yin (ORCID: https://orcid.org/0009-0001-1496-1107)
- Linhong Yao
Institutions
- Guangdong Medical College (CN)
- First Hospital of China Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Diabetology & Metabolic Syndrome
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1186/s13098-025-01856-9
- Citations
- 1
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 1.43
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Guangdong Province
- China Medical University