IRF4 Promotes Immune Evasion and Shapes the Tumor Microenvironment in Follicular Lymphoma
We show that IRF4 controls immune and metabolic signaling with functional effects on the cross-talk between B and T cells, resulting in a suppressive immune microenvironment when IRF4 is overexpressed in lymphoma. This underscores the importance of IRF4 as a pivotal therapeutic target to restore antitumor immunosurveillance for IRF4-associated lymphomas.
Authors
- Vaishali Bhardwaj (ORCID: https://orcid.org/0000-0002-2880-0187)
- Johannes L. Zakrzewski (ORCID: https://orcid.org/0000-0002-5323-0630)
- Kerstin Wenzl (ORCID: https://orcid.org/0000-0002-3363-1795)
- Bruno M. Tesson (ORCID: https://orcid.org/0009-0006-0700-0240)
- Harinder Singh (ORCID: https://orcid.org/0000-0002-6330-8526)
- Laura Pasqualucci (ORCID: https://orcid.org/0000-0001-6819-7370)
- Rebecca L. King (ORCID: https://orcid.org/0000-0002-7132-0226)
- Anne J. Novak (ORCID: https://orcid.org/0000-0002-7904-1651)
- José C. Villasboas (ORCID: https://orcid.org/0000-0002-2907-0809)
- Patrizia Mondello (ORCID: https://orcid.org/0000-0002-0355-3757)
- Brianna J. Negaard (ORCID: https://orcid.org/0000-0001-7592-8952)
- Franck Morschhauser (ORCID: https://orcid.org/0000-0002-3714-9824)
- Loïc Chartier (ORCID: https://orcid.org/0009-0006-0588-3684)
- Matthew J. Maurer (ORCID: https://orcid.org/0000-0002-1867-0526)
- Stephen M. Ansell (ORCID: https://orcid.org/0000-0003-1244-6758)
- Geoffrey M. Nelson (ORCID: https://orcid.org/0000-0001-9825-4241)
- Grzegorz S. Nowakowski (ORCID: https://orcid.org/0000-0002-6955-9393)
- Zhi-Zhang Yang (ORCID: https://orcid.org/0000-0002-1468-2300)
- Surendra Dasari (ORCID: https://orcid.org/0000-0002-7972-3556)
- Xinyi Tang (ORCID: https://orcid.org/0000-0002-1889-4562)
- Karen Louise Adelman (ORCID: https://orcid.org/0000-0001-5364-334X)
- Mark J. Shlomchik (ORCID: https://orcid.org/0000-0002-2152-0959)
- Sarah Huet (ORCID: https://orcid.org/0000-0002-3408-2783)
- Prithviraj Mukherjee (ORCID: https://orcid.org/0009-0007-7779-8814)
- Emmanuel Contreras Guzman (ORCID: https://orcid.org/0000-0002-1929-3961)
- Zhiquan Wang (ORCID: https://orcid.org/0000-0002-8243-7251)
- Joshua Olson (ORCID: https://orcid.org/0000-0002-1306-7867)
Institutions
- Mayo Clinic (US)
- Harvard University (US)
- University of Pittsburgh (US)
- Université de Lille (FR)
- Harvard University Press (US)
- WinnMed (US)
- Centre Hospitalier Universitaire de Lille (FR)
- Lille’s Cardiology Hospital (FR)
- Hospices Civils de Lyon (FR)
- The Lymphoma Academic Research Organisation (FR)
- Hôpital Lyon Sud (FR)
- Mayo Clinic in Arizona (US)
- Cancer Genetics (United States) (US)
- Mayo Clinic in Florida (US)
- Hackensack Meridian Health (US)
- Institut Carnot ARTS (FR)
- Center for Discovery (US)
- Centre International de Recherche en Infectiologie (FR)
- Columbia University (US)
Publication Details
- Journal
- Blood Cancer Discovery
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1158/2643-3230.bcd-24-0223
- Primary Topic
- Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00