<i>Mycobacterium tuberculosis</i> Infection of Retinal Endothelial Cells Induces Interferon Signaling Activation: Insights Into Tubercular Retinal Vasculitis
RECs elicit a robust immune response to Mtb infection. IFN signaling activation was observed in live Mtb-infected RECs but not in HK-Mtb-exposed RECs. These findings provide insights into TRV pathogenesis and offer clues for potential biomarkers that may help differentiate TRV caused by active infection, which requires antitubercular treatment, from cases without active infection, which require immunosuppressive therapy alone.
Authors
- Nicole M. A. Nagtzaam
- P. Martin van Hagen (ORCID: https://orcid.org/0000-0003-0854-2368)
- Conny van Holten-Neelen
- Rina La Distia Nora (ORCID: https://orcid.org/0000-0002-7026-5341)
- Jurriaan E.M. de Steenwinkel (ORCID: https://orcid.org/0000-0001-8437-1025)
- Saskia M. Rombach (ORCID: https://orcid.org/0000-0003-1356-7033)
- Willem A. Dik (ORCID: https://orcid.org/0000-0001-5235-3156)
- Ikhwanuliman Putera (ORCID: https://orcid.org/0000-0002-9350-5133)
- Sigrid M. A. Swagemakers
Institutions
- Chulalongkorn University (TH)
- Erasmus MC (NL)
- Medisch Centrum Haaglanden (NL)
- Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo (ID)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1167/iovs.66.9.48
- Citations
- 1
- Primary Topic
- Ocular Diseases and Behçet’s Syndrome
- Type
- article
- Field-Weighted Citation Impact
- 1.71