Inhibition of Endothelial HIF-1α by IDF-11774 Attenuates Retinal Neovascularization and Vascular Leakage
Inhibiting HIF-1α with IDF-11774 exerts multiple therapeutic and pathway-regulatory effects and demonstrates a favorable retinal safety profile, highlighting IDF-11774 as a potentially therapeutic strategy for IR.
Authors
- Andina Hu (ORCID: https://orcid.org/0009-0002-2772-030X)
- Fengmei Yang (ORCID: https://orcid.org/0000-0001-7261-7219)
- Kun Xu (ORCID: https://orcid.org/0000-0002-2671-4170)
- Changxuan Liu
- Boyu Yang (ORCID: https://orcid.org/0000-0001-8398-1753)
- Peiqi Wu
- Jicheng Lin (ORCID: https://orcid.org/0000-0003-0689-9398)
- Yue Xu (ORCID: https://orcid.org/0000-0002-3447-5608)
- Shanshan Yu (ORCID: https://orcid.org/0000-0002-5338-3813)
- Xi Lü (ORCID: https://orcid.org/0000-0002-5056-8249)
- Haolin Kong
- Kaixuan Cui (ORCID: https://orcid.org/0009-0006-0929-0819)
- Xiaoling Liang (ORCID: https://orcid.org/0000-0001-8506-6225)
Institutions
- Sun Yat-sen University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1167/iovs.66.9.47
- Citations
- 1
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.71