UCP2 inhibition exaggerates diabetic cardiomyopathy by facilitating the activation of NLRP3 and pyroptosis
UCP2 inhibition exacerbates DCM by inducing NLRP3- and GSDMD-mediated pyroptosis via the ROS/TXNIP axis. These findings offer new insights into DCM pathogenesis and potential therapeutic targets.
Authors
- Jinglei Niu
- Chenchen Ai
- Lixia Zhang (ORCID: https://orcid.org/0000-0002-9463-6039)
- Zheng Zhang (ORCID: https://orcid.org/0009-0003-1304-9735)
- Changlei Guo
- Xiaoxue Meng
- S. Li (ORCID: https://orcid.org/0000-0003-1673-2794)
Institutions
- Gansu Provincial Maternal and Child Health Hospital (CN)
- First Hospital of Lanzhou University (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Diabetology & Metabolic Syndrome
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1186/s13098-025-01855-w
- Citations
- 3
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Lanzhou University
- Natural Science Foundation of Gansu Province