Discovery, Structural Revision, Heterologous Production, and Biosynthesis of Mintaimycins from Marine-Derived <i>Micromonospora</i> sp. SCSIO 80128
<i>Micromonospora</i>, a large group of actinomycetes, is increasingly important in natural products discovery. Genus-based metabologenomic analyses and OSMAC tactics unveiled three known (<b>1</b>, <b>3</b>, and <b>6</b>) and three new mintaimycins (<b>2</b>, <b>4</b>, and <b>5</b>) from marine-derived <i>Micromonospora</i> sp. SCSIO 80128. All absolute configurations were unambiguously established by X-ray diffraction and their biosynthetic gene cluster (<i>min</i>) was validated by heterologous expression. Bioinformatics and gene inactivation studies support a newly proposed biosynthetic pathway to <b>1</b>-<b>6</b>.
Authors
- Zhenbin Zhou
- Jianhua Ju (ORCID: https://orcid.org/0000-0001-7712-8027)
- Xinpeng Tian (ORCID: https://orcid.org/0000-0001-5871-0062)
- Jiafan Yang (ORCID: https://orcid.org/0000-0001-5703-0890)
- Junying Ma (ORCID: https://orcid.org/0000-0002-0641-7291)
- Changli Sun
- Xiaohua Li (ORCID: https://orcid.org/0000-0003-2482-9000)
Institutions
- Shandong University (CN)
- Institute of Oceanology (CN)
- South China Sea Institute Of Oceanology (CN)
- Institute of Oceanology (BG)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1021/acs.orglett.5c02239
- Citations
- 2
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 2.79